Digitalis, digitoxin, digoxin, Coley toxins, cytokines, cancer

PubMed  

Coley toxins in The Lancet    HauxTLDPletterDec2000PDF   

Digitoxin has Specific Properties for Potential use to Treat Cancer and Inflammatory Diseases

ColeyatWaldorfAstoria:   side1   side2  side3

Targeting the cytokine storm induced by some viral infections, Digitalis for Bird Flu?  10 January 2006  J. Haux   ,  may change the course of serious bird flu, as indicated in a recent case report:: Cytotoxic therapy for severe swine flu A/H1N1, The Lancet 18 Dec 2010

Pro-apoptotic and cytostatic activity of naturally occurring cardenolides.
Cancer Chemother Pharmacol. 2009 Sep;64(4):793-802

Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5.
Cancer Res. 2006 Jun 1;66(11):5867-74.

The dynamics of cell proliferation.
Moxnes JF, Haux J, Hausken K.

Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs. Felth J, Rickardson L, Rosén J, Wickström M, Fryknäs M, Lindskog M, Bohlin L, Gullbo J. J Nat Prod. 2009 Nov;72(11):1969-74.

Digitoxin elicits anti-inflammatory and vasoprotective properties in endothelial cells: Therapeutic implications for the treatment of atherosclerosis ? Atherosclerosis, In Press, Accepted Manuscript, Available online 25 March 2009
Joanna Jagielska, Gustavo Salguero, Bernhard Schieffer, Udo Bavendiek

Novel therapeutic applications of cardiac glycosides. Prassas I, Diamandis EP. Nat Rev Drug Discov. 2008 Nov;7(11):926-35.

Cardiac glycosides as novel cancer therapeutic agents. Mol Interv. 2008 Feb;8(1):36-49.Newman RA, Yang P, Pawlus AD, Block KI.M. D. Anderson Cancer Center, Houston, TX

Anti-HSV activity of digitoxin and its possible mechanisms  Antiviral Research, In Press, Uncorrected Proof, Available online 21 February 2008

Interview in Swedish about ongoing prostate cancer study (digitoxin for androgen independent prostate cancer) , September 28, 2007 Researcher`s Night, Skövde

Not active:  A pilot phase II study of digitoxin for Androgen-Independent Prostate Cancer (AIPC) March 2007  Principal investigator J. Haux

Cardiac Glycosides Initiate Apo2L/TRAIL-Induced Apoptosis in Non–Small Cell Lung Cancer Cells by Up-regulation of Death Receptors 4 and 5

Digitoxin Inhibits the Growth of Cancer Cell Lines at Concentrations Commonly Found in Cardiac Patients   October 18, 2005

Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization   PNAS August 16, 2005

BBC News August, 2005

University of Wisconsin News

Multiplex Gene Expression Analysis for High-Throughput Drug Discovery: Screening and Analysis of Compounds Affecting Genes Overexpressed in Cancer Cells    Dec. 2002

Foxgloves can fight cancer Gemini 2001

Dr.HauxBadenBaden-98video

Cardiac glycosides inhibit TNF-{alpha}/ NF- {kappa}B signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9631-6.

Old drugs – new uses  

The dynamics of cell proliferation.

Med Hypotheses. 2004;62(4):556-63.

Digitalis; impinges on more than just the (ion-) pump.

Med Hypotheses. 2002 Dec;59(6):781-2.

 

Digitoxin medication and cancer; case control and internal dose-response studies.

BMC Cancer. 2001;1(1):11.

Infection and cancer.

Lancet. 2001 Jul 14;358(9276):155-6.  

HauxTLDPdec2000.pdf

Digitalis: The Insulin for Cancer? April 17, 2006

Some information in Norwegian and some more in Legemidler og samfunn

Digitoxin is a potential anticancer agent for several types of cancer.

Med Hypotheses. 1999 Dec;53(6):543-8.

Digitoxin, in non-toxic concentrations, inhibits proliferation and induces cell death in prostate cancer cell lines

Z Onkol 2000; 32: 11-16

Digitoxin, in non toxic concentrations, induces apoptotic cell death in Jurkat T cells in vitro.

Haux J, Lam M, Marthinsen ABL, Strickert  T, Lundgren S.

Z Onkol 1999;31: 14-20

  Digitoxin sensitizes malignant breast cancer cells for radiation in vitro.

Haux J, Marthinsen ABL, Gulbrandsen M, Alfredsen AS, Johansen H, Strickert.

Z Onkol 1999;31: 61-65

Regulation of APO-2 ligand/trail expression in NK cells-involvement in NK cell-mediated cytotoxicity.

Cytokine. 1999 Sep;11(9):664-72.

The role of interleukin-2 in regulating the sensitivity of natural killer cells for Fas-mediated apoptosis.

Cancer Immunol Immunother. 1999 May-Jun;48(2-3):139-46.

Regulation of Fas and Fas-ligand expression in NK cells by cytokines and the involvement of Fas-ligand in NK/LAK cell-mediated cytotoxicity.

Cytokine. 1997 Jun;9(6):394-404.

 

Address reprint requests and correspondence to:

Johan Haux, MD, PhD  jhaux@operamail.com